From cradle to grave: high-throughput studies of aging in model organisms.
نویسندگان
چکیده
Aging-the progressive decline of biological functions-is a universal fact of life. Decades of intense research in unicellular and metazoan model organisms have highlighted that aging manifests at all levels of biological organization - from the decline of individual cells, to tissue and organism degeneration. To better understand the aging process, we must first aim to integrate quantitative biological understanding on the systems and cellular levels. A second key challenge is to then understand the many heterogeneous outcomes that may result in aging cells, and to connect cellular aging to organism-wide degeneration. Addressing these challenges requires the development of high-throughput aging and longevity assays. In this review, we highlight the emergence of high-throughput aging approaches in the most commonly used model organisms. We conclude with a discussion of the critical questions that can be addressed with these new methods.
منابع مشابه
Cradle to Grave : The Environmental Impacts from Coal Cradle to Grave : The Environmental Impacts from Coal Clean Air Task
متن کامل
Human Virome
Viruses are dominant entities in the biosphere and parasitize all cellular life forms. The relative abundances of different classes of viruses are dramatically different between prokaryotes and eukaryotes. In marine, soil and animal-associated environments, virus particles consistently outnumber cells by one to two orders of magnitude. It is estimated that 10 quintillion (1030) viral particles ...
متن کاملSaga of Discrimination of Girl Child in India
Girls in India face discrimination from cradle to grave in different forms and in different arenas of life. However, it is long survival of women compare to men (due to menopause older women free from risk of bearing children in later life and live longer (Cromie, 1998), which makes them 48% of population (Census, 2011). At every step, she is in patriarchal shackles with no opportunity to escap...
متن کاملA short overview about cadmium and its toxicity focused on humans, bioindicators and model organisms
According to Paracelsus (1493-1541) everything from this planet is poison, only the dose makes the poison to be harmless. Even the essential elements for life support are toxic for all organisms in high amounts. Mercury, cadmium, metalloid arsenic and lead were responsible for poisoning and death of many humans and life forms from this planet for centuries. Cadmium forms different compounds tha...
متن کاملCan Light Emitted from Smartphone Screens and Taking Selfies Cause Premature Aging and Wrinkles?
Since the early days of human life on the Earth, our skin has been exposed to different levels of light. Recently, due to inevitable consequences of modern life, humans are not exposed to adequate levels of natural light during the day but they are overexposed to relatively high levels of artificial light at night. Skin is a major target of oxidative stress and the link between aging and oxidat...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Molecular bioSystems
دوره 10 7 شماره
صفحات -
تاریخ انتشار 2014